Beilstein J. Nanotechnol.2021,12, 786–797, doi:10.3762/bjnano.12.62
absolute telomerelength (TL) measurement, and gene and protein assessment of the cells, respectively. It was found that 2.5 µg/mL Ag-NPs caused elongation of the telomeres and altered VEGF, C-TnI, VWF, SMA, GATA-4, TERT, and cyclin D protein and gene expression in the cardiomyogenically differentiated BM
; cardiomyogenic differentiation; silver nanoparticles; telomerelength; Wnt3/β-catenin signaling pathway; Introduction
Cardiac disorders that eventually lead to heart failure cause an increased loss of cardiac cells. There is strong evidence that the progression of heart failure is associated with reduction in
and the control group (*p < 0.05). For this reason, a concentration of 2.5 µg/mL of Ag-NPs was selected for cell treatment. Also, this concentration was previously reported by Sengstock and co-workers [11].
Ag-NPs increase the absolute telomerelength (aTL)
The aTL was measured by the quantitative
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Figure 1:
Morphology of BM-MSCs; (A) Fibroblast-like morphology of cells that appear 24 h after cell seeding ...